MovDisordV3, France, Analysis, bibRecord, 000246

Motor‐related circuit dysfunction in MSA‐P: Usefulness of combined whole‐brain imaging analysis

Identifieur interne : 000246 ( France/Analysis ); précédent : 000245; suivant : 000247

Motor‐related circuit dysfunction in MSA‐P: Usefulness of combined whole‐brain imaging analysis

Auteurs : Mélissa Tir [France] ; Christine Delmaire [France] ; Vianney Le Thuc [France] ; Alain Duhamel [France] ; Alain Destée [France] ; Jean-Pierre Pruvo [France] ; Luc Defebvre [France]

Source :

Movement Disorders [ 0885-3185 ] ; 2009-04-30.

RBID : ISTEX:42E49C9BED3CD62552BDC932F427A78766B77349

Descripteurs français

Pascal (Inist)
- Atrophie multisystématisée, Cortex moteur, Encéphale, Imagerie RMN, Imagerie de diffusion, Maladie de Parkinson, Pathologie du système nerveux, Trouble fonctionnel.

English descriptors

Abstract

The aim of this study was to evaluate in vivo changes in the brain's macro‐ and microstructure (notably in the motor system) in the parkinsonian variant of multiple system atrophy (MSA‐P) and in Parkinson's disease (PD) and to characterize the cerebral anatomical differences between the two conditions. We used a combination of voxel‐based morphometry (VBM) and whole‐brain, voxel‐based diffusion tensor imaging analysis (VB‐DTI). Forty‐seven right‐handed subjects (14 MSA‐P patients, 19 PD patients, and 14 controls) were evaluated using VBM and VB‐DTI in an analysis of covariance (ANCOVA) with a significance threshold set to P < 0.005. In MSA‐P patients, VBM analysis revealed a lower density of grey matter (GM) in a motor‐related circuit (especially in the left primary motor cortex, PMC), relative to PD patients, and in the left supplementary motor area (SMA), relative to controls). Diffusion tensor imaging analysis revealed lower fractional anisotropy (FA) values in the left PMC and the right cerebellum in MSA‐P patients, compared with controls. Using a volumetric diffusion technique, our study revealed selective tissue degeneration in motor circuits, regardless of the volume loss detected in VBM and in agreement with pathology reports and clinical motor characteristics. Our findings suggest that MSA‐P is characterized by both macro‐ and microstructural changes in the sensorimotor circuit. © 2009 Movement Disorder Society

Url:

https://api.istex.fr/document/42E49C9BED3CD62552BDC932F427A78766B77349/fulltext/pdf

DOI: 10.1002/mds.22463

Affiliations:

Links to Exploration step

ISTEX:42E49C9BED3CD62552BDC932F427A78766B77349

Le document en format XML

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<front><div type="abstract" xml:lang="en">The aim of this study was to evaluate in vivo changes in the brain's macro‐ and microstructure (notably in the motor system) in the parkinsonian variant of multiple system atrophy (MSA‐P) and in Parkinson's disease (PD) and to characterize the cerebral anatomical differences between the two conditions. We used a combination of voxel‐based morphometry (VBM) and whole‐brain, voxel‐based diffusion tensor imaging analysis (VB‐DTI). Forty‐seven right‐handed subjects (14 MSA‐P patients, 19 PD patients, and 14 controls) were evaluated using VBM and VB‐DTI in an analysis of covariance (ANCOVA) with a significance threshold set to P < 0.005. In MSA‐P patients, VBM analysis revealed a lower density of grey matter (GM) in a motor‐related circuit (especially in the left primary motor cortex, PMC), relative to PD patients, and in the left supplementary motor area (SMA), relative to controls). Diffusion tensor imaging analysis revealed lower fractional anisotropy (FA) values in the left PMC and the right cerebellum in MSA‐P patients, compared with controls. Using a volumetric diffusion technique, our study revealed selective tissue degeneration in motor circuits, regardless of the volume loss detected in VBM and in agreement with pathology reports and clinical motor characteristics. Our findings suggest that MSA‐P is characterized by both macro‐ and microstructural changes in the sensorimotor circuit. © 2009 Movement Disorder Society</div>
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Movement Disorders (revue)

Motor‐related circuit dysfunction in MSA‐P: Usefulness of combined whole‐brain imaging analysis

Motor‐related circuit dysfunction in MSA‐P: Usefulness of combined whole‐brain imaging analysis

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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